Skype contains multiple vulnerabilities. Successful exploitation could result in a wide variety of conditions, including denial of service and remote code execution.
Skype v5.3.x, v5.2.x, v2.2.x
Remote Code Execution
This client-side vulnerability could allow an attacker to gain the ability to execute arbitrary code in the context of the current application. If the application is run as Administrator, the attacker may gain complete control of the target system.
BeyondTrust Prevention and Detection:
No mitigation has been provided.